About L-FABP

Mechanism of expression

Schematic diagram of glomerulus and renal tubule

A highly sensitive renal biomarker

L-FABP is a kind of “fatty acid binding proteins” with a molecular weight of 14kDa located in the cytoplasm of human renal proximal tubular cells.

L-FABPs are excreted in urine due to:
  • ischemia (or low capillary blood flow) and
  • oxidative stress on renal tubule
before progression of tissue damage
Useful for early diagnosis of renal disease accompanying tubular dysfunction
Tubular ischemia

Increase of oxidative stress


Conventional markers are excreted in urine due to tissue damage in the glomerulus and renal tubule.

Glomerular damage

Dysfunction of filtration

Albumin (Alb)
Type IV collagen
Disorder of tubular reabsorption


Tubular injury / inflammation


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For nonclinical safety evaluation

Urinary L-FABP kits for Rat, Dog, Cat, Monkey and Pig are available for the purpose of monitoring drug nephrotoxicity and drug effectiveness.
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