About L-FABP
Mechanism of expression
Schematic diagram of glomerulus and renal tubule
A highly sensitive renal biomarker
L-FABP is a kind of “fatty acid binding proteins” with a molecular weight of 14kDa located in the cytoplasm of human renal proximal tubular cells.
L-FABPs are excreted in urine due to:- ischemia (or low capillary blood flow) and
- oxidative stress on renal tubule
↓ Useful for early diagnosis of renal disease accompanying tubular dysfunction
Tubular ischemia
↓
Increase of oxidative stress
↓
L-FABP
↓
Increase of oxidative stress
↓
L-FABP
Conventional markers are excreted in urine due to tissue damage in the glomerulus and renal tubule.
Glomerular damage
↓
Dysfunction of filtration
↓
Albumin (Alb)
Type IV collagen
↓
Dysfunction of filtration
↓
Albumin (Alb)
Type IV collagen
Disorder of tubular reabsorption
↓
β2-MG
α1-MG
Tubular injury / inflammation
↓
NAG
↓
β2-MG
α1-MG
Tubular injury / inflammation
↓
NAG
